O6-甲基鸟嘌呤-DNA甲基转移酶的下调增强了替莫唑胺对黑色素瘤细胞的作用。 - Suppr | 超能文献

Down-regulation of O6-methylguanine-DNA methyl transferase enhances the effect of temozolomide in melanoma cells.

作者信息

Jiang Guan, Zheng Jun-Nian, Liu Yan-Qun

出版信息

Med Hypotheses. 2011 Jan;76(1):147-8. doi: 10.1016/j.mehy.2010.09.024. Epub 2010 Nov 1.

DOI:10.1016/j.mehy.2010.09.024

Abstract

摘要

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MGMT inhibition in ER positive breast cancer leads to CDC2, TOP2A, AURKB, CDC20, KIF20A, Cyclin A2, Cyclin B2, Cyclin D1, ERα and Survivin inhibition and enhances response to temozolomide.在雌激素受体阳性乳腺癌中抑制O-6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）会导致细胞周期蛋白依赖性激酶2（CDC2）、拓扑异构酶Ⅱα（TOP2A）、极光激酶B（AURKB）、细胞分裂周期蛋白20（CDC20）、驱动蛋白家族成员20A（KIF20A）、细胞周期蛋白A2（Cyclin A2）、细胞周期蛋白B2（Cyclin B2）、细胞周期蛋白D1（Cyclin D1）、雌激素受体α（ERα）和生存素（Survivin）受到抑制，并增强对替莫唑胺的反应。

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