Cardiovascular Unit, UCL Institute of Child Health, London, United Kingdom.
EuroIntervention. 2010 Nov;6(5):638-42. doi: 10.4244/EIJV6I5A106.
To investigate the impact of balloon inflation pressure and balloon diameter on the expansion forces exerted in a stenosed vessel (congenital heart disease applications) using computational models.
A simplified three-dimensional model of a vessel with a cylindrical stenosis was created. Two low-compliance balloons with different inflation diameters (10 vs. 16 mm) were modelled. Finite element simulations of balloon expansions were performed. To dilate the stenosis from 4 to 10 mm lumen diameter, the large balloon needed less inflation pressure than the small balloon (0.55 vs. 1.00 MPa). Under these circumstances, the large balloon also achieved higher stresses at the stenotic vessel site (5.23 ± 0.10 vs. 3.97 ± 0.04 MPa, p<0.001). When using inflation pressures that led to equal surface stresses of both balloons, the large balloon could exert higher expansion forces onto the stenotic site, achieving higher stresses (5.18 ± 0.09 vs. 3.38 ± 0.01 MPa, p<0.001) and greater lumen diameter (9.73 vs. 8.68 mm).
In a computerised model of balloon dilatation, balloon diameter had a greater impact on the expansion force than inflation pressure. This finding emphasises the importance of choosing an appropriate balloon diameter to achieve optimal haemodynamic outcomes.
使用计算模型研究球囊膨胀压力和球囊直径对狭窄血管（先天性心脏病应用）扩张力的影响。
创建了一个具有圆柱状狭窄的简化三维血管模型。模拟了两个不同膨胀直径（10 毫米与 16 毫米）的低顺应性球囊。进行了球囊膨胀的有限元模拟。为了将狭窄从 4 扩张至 10 毫米管腔直径，大球囊所需的膨胀压力小于小球囊（0.55 兆帕与 1.00 兆帕）。在这种情况下，大球囊在狭窄血管部位也产生了更高的应力（5.23 ± 0.10 兆帕与 3.97 ± 0.04 兆帕，p<0.001）。当使用导致两个球囊表面应力相等的膨胀压力时，大球囊可以向狭窄部位施加更高的扩张力，产生更高的应力（5.18 ± 0.09 兆帕与 3.38 ± 0.01 兆帕，p<0.001）和更大的管腔直径（9.73 毫米与 8.68 毫米）。
在球囊扩张的计算机模型中，球囊直径对扩张力的影响大于膨胀压力。这一发现强调了选择适当球囊直径以实现最佳血液动力学结果的重要性。
