Ramezani Amitis, Banifazl Mohammad, Eslamifar Ali, Aghakhani Arezoo
Clinical Research Department, Pasteur Institute of Iran, Tehran, Iran.
J Infect Dev Ctries. 2010 Oct 28;4(10):658-61. doi: 10.3855/jidc.728.
Anti-hepatitis B core antibody (Anti-HBc) alone is defined as the presence of anti-HBc in the absence of HBsAg and anti-HBs. The significance of this serological pattern as a predicting factor for occult hepatitis B virus (HBV) infection remains largely unknown. This study aimed to assess the significance of anti-HBc alone in predicting occult HBV infection in high-risk and low-risk individuals.
A total of 926 individuals were enrolled in this study, including 289 hemodialysis (HD) and 106 HIV-infected patients who were considered as a high-risk group and 531 blood donors who were considered as low-risk. HBsAg, anti-HBs, anti-HBc were tested in all subjects. The presence of HBV-DNA was determined quantitatively in patients with anti-HBc alone by real-time PCR.
Of the 395 high-risk patients, 40 cases (10.13%) had anti-HBc alone, while 11 subjects (2.07%) out of 531 blood donors had anti-HBc alone. HBV-DNA was detected in 12 out of 40 (30%) high-risk patients and none of the blood donors with anti-HBc alone.
Our study showed that the serological pattern of anti-HBc alone could reflect occult HBV infection in high risk cases but did not presume occult HBV infection in low-risk individuals.
单独的抗乙肝核心抗体（抗-HBc）定义为在不存在乙肝表面抗原（HBsAg）和抗-HBs的情况下抗-HBc的存在。这种血清学模式作为隐匿性乙型肝炎病毒（HBV）感染预测因素的意义在很大程度上仍不清楚。本研究旨在评估单独抗-HBc在预测高危和低危个体隐匿性HBV感染中的意义。
本研究共纳入926名个体，包括289名血液透析（HD）患者和106名HIV感染患者，他们被视为高危组，以及531名献血者，他们被视为低危组。对所有受试者检测HBsAg、抗-HBs、抗-HBc。通过实时PCR对单独抗-HBc的患者定量检测HBV-DNA的存在情况。
在395名高危患者中，40例（10.13%）单独存在抗-HBc，而在531名献血者中有11名（2.07%）单独存在抗-HBc。40名高危患者中有12名（30%）检测到HBV-DNA，而单独抗-HBc的献血者均未检测到。
我们的研究表明，单独抗-HBc的血清学模式可反映高危病例中的隐匿性HBV感染，但不能推断低危个体存在隐匿性HBV感染。
