Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Neurol India. 2010 Sep-Oct;58(5):761-3. doi: 10.4103/0028-3886.72184.
D-penicillamine induced status dystonicus is a unique but serious drug related complication in a subset of patients with Wilson disease. Patho-physiological basis of its occurrence is not known. It often responds poorly to anti dystonia medications. We present three patients with Wilson disease who developed severe paroxysmal dystonic spells after receiving D-penicillamine treatment. All three patients responded well to gabapentin after failing to respond to other anti dystonia drugs.
青霉胺诱导的张力障碍状态是肝豆状核变性患者亚群中一种独特但严重的与药物相关的并发症。其发病的病理生理基础尚不清楚。它通常对抗张力障碍药物反应不佳。我们介绍了 3 例接受青霉胺治疗后出现严重阵发性张力障碍发作的肝豆状核变性患者。在对其他抗张力障碍药物反应不佳后，所有 3 例患者均对加巴喷丁反应良好。
