Department of Ophthalmology, University of South Carolina, Columbia, SC, USA.
Cornea. 2011 Apr;30(4):388-91. doi: 10.1097/ICO.0b013e3181f236c6.
To evaluate visual acuity outcomes after endothelial keratoplasty (EK) and describe the relationship to postoperative central corneal graft thickness as measured by anterior segment optical coherence tomography (AS-OCT).
A retrospective case series of 33 eyes in 28 patients undergoing routine EK using precut eye bank tissue was designed. All patients underwent serial central graft thickness measurements with AS-OCT. Based on the median central graft thickness of all patients, the eyes were divided into 2 groups: thin EK and thick EK. Differences between the groups were compared.
The median postoperative graft thickness of all eyes was 131 μm. The eyes were divided into 2 groups based on this median: thin EK (graft thickness: ≤ 131 μm; range: 77-131 μm; average: 109 μm) and thick EK (graft thickness: > 131 μm; range: 138-182 μm; average: 162 μm). There was no statistically significant difference in age, sex, or preoperative best spectacle-corrected visual acuity (BSCVA) between the 2 groups. Average postoperative follow-up was 12.8 months. The thin EK group showed better postoperative BSCVA compared with the thick EK group (P < 0.01). All thin EK eyes had BSCVA greater than or equal to 20/25 with 71% of eyes achieving BSCVA of 20/20. In contrast, only 50% of thick EK eyes reached BSCVA greater than or equal to 20/25 with 19% obtaining BSCVA of 20/20.
Thin EK versus thick EK, as measured by AS-OCT in the postoperative period, showed a statistically significant improvement in BSCVA.
评估内皮角膜移植（EK）后的视力结果，并描述通过眼前段光学相干断层扫描（AS-OCT）测量的术后中央角膜移植物厚度的关系。
设计了一项回顾性病例系列研究，纳入了 28 名患者的 33 只眼，这些患者均接受了使用预先切割的眼库组织的常规 EK。所有患者均接受了 AS-OCT 对中央移植物厚度的连续测量。根据所有患者的中央移植物厚度中位数，将这些眼分为两组：薄 EK 和厚 EK。比较两组之间的差异。
所有眼的术后移植物平均厚度为 131μm。根据该中位数，这些眼被分为两组：薄 EK（移植物厚度：≤131μm；范围：77-131μm；平均：109μm）和厚 EK（移植物厚度：>131μm；范围：138-182μm；平均：162μm）。两组之间在年龄、性别或术前最佳矫正视力（BSCVA）方面无统计学差异。平均术后随访时间为 12.8 个月。薄 EK 组的术后 BSCVA 优于厚 EK 组（P<0.01）。所有薄 EK 眼的 BSCVA 均大于或等于 20/25，其中 71%的眼达到了 20/20 的 BSCVA。相比之下，只有 50%的厚 EK 眼的 BSCVA 大于或等于 20/25，其中 19%的眼达到了 20/20 的 BSCVA。
通过 AS-OCT 在术后测量，薄 EK 与厚 EK 相比，BSCVA 有显著改善。
