Research Development and Innovation Department, VISSUM Instituto Oftalmológico de Alicante, Spain.
Cornea. 2011 Mar;30(3):301-7. doi: 10.1097/ICO.0b013e3181eeb0c1.
To determine if superficial lamellar corneal excision with femtosecond laser followed by phototherapeutic keratectomy (PTK) using a masking substance improves visual acuity and optical quality of patients with severe corneal opacities.
Twelve eyes with corneal haze or scarring underwent confocal microscopy to estimate the opacities' thickness and calculate the excision depth. Femtosecond laser was then used to create a superficial corneal flap. PTK and smoothening with masking substance (0.25% sodium hyaluronate) were done to improve corneal regularity and decrease corneal scarring. Follow-up was performed at 1, 6, and 12 months.
Mean logarithm of the minimum angle of resolution of best spectacle-corrected visual acuity improved from 0.62 (mean decimal 0.26) to 0.30 (mean decimal 0.58) at 1 year (P = 0.035). Haze grades improved significantly. Coma-like aberration decreased postoperatively.
Results showed that superficial corneal excision with femtosecond laser augmented with PTK laser smoothening assisted with 0.25% sodium hyaluronate improved visual acuity and could be considered as an alternative to more invasive procedures in patients with severe corneal opacities.
确定飞秒激光辅助下的浅层角膜切削术联合使用遮蔽物质的光化学角膜切削术(PTK)是否可以提高严重角膜混浊患者的视力和光学质量。
对 12 只角膜混浊或瘢痕的眼睛进行共焦显微镜检查,以评估混浊的厚度并计算切除深度。然后使用飞秒激光制作浅层角膜瓣。进行 PTK 和使用遮蔽物质(0.25%透明质酸钠)进行平滑处理,以改善角膜的规则性并减少角膜瘢痕。在 1、6 和 12 个月进行随访。
最佳矫正视力的最小分辨角对数的平均值从 1 年时的 0.62(平均十进制为 0.26)提高到 0.30(平均十进制为 0.58)(P = 0.035)。混浊程度显著改善。彗差像差术后降低。
结果表明,飞秒激光辅助下的浅层角膜切削术联合使用 PTK 激光平滑处理辅助 0.25%透明质酸钠可以提高视力,可以作为严重角膜混浊患者更具侵袭性手术的替代方法。