Department of Neonatology, Bambino Gesù Children's Hospital, Roma 00165, Italy.
Pediatr Res. 2011 Feb;69(2):142-7. doi: 10.1203/PDR.0b013e3182042496.
Bronchopulmonary dysplasia (BPD) is a common adverse outcome of prematurity, causing severe morbidity and mortality. The cytokine macrophage migration inhibitory factor (MIF) has been recently shown to favor murine fetal lung development. In this prospective study, we evaluate the expression of MIF in the lung and in the serum of preterm infants (n = 50) and investigate whether the -173 G/C MIF promoter polymorphism is associated with the risk of BPD (n = 103). MIF was highly expressed in lung tissue from preterm infants. Serum MIF levels were measured by ELISA at d 1 after birth. MIF levels were increased [median (interquartile range), 71.01 (44.9-162.3) ng/mL], particularly in those infants with RDS [110.4 (59.4-239.2) ng/mL] compared with healthy adults [2.4 (1.2-5.0) ng/mL], (p < 0.001). The MIF -173C allele, which predisposes to higher MIF production, was associated with a lower incidence of BPD (OR, 0.2; 95% CI, 0.04-0.93), independently from mechanical ventilation and oxygen exposure (p = 0.03). In conclusion, these data show that MIF expression is increased in lung and serum of preterm infants and suggest that the high producing MIF -173C allele may be a protective factor for BPD.
支气管肺发育不良（BPD）是早产儿的常见不良后果，导致严重的发病率和死亡率。细胞因子巨噬细胞移动抑制因子（MIF）最近被证明有利于鼠胎儿肺发育。在这项前瞻性研究中，我们评估了 MIF 在早产儿肺组织和血清中的表达，并研究了-173 G/C MIF 启动子多态性是否与 BPD 风险相关（n=103）。MIF 在早产儿肺组织中高度表达。通过 ELISA 在出生后第 1 天测量血清 MIF 水平。MIF 水平升高[中位数（四分位数范围），71.01（44.9-162.3）ng/mL]，特别是在患有 RDS 的婴儿中[110.4（59.4-239.2）ng/mL]与健康成年人[2.4（1.2-5.0）ng/mL]相比，（p<0.001）。易导致 MIF 产生增加的-173C 等位基因与 BPD 发生率降低相关（OR，0.2；95%CI，0.04-0.93），独立于机械通气和氧暴露（p=0.03）。总之，这些数据表明 MIF 在早产儿肺和血清中的表达增加，并表明高表达 MIF-173C 等位基因可能是 BPD 的保护因素。
