通过免疫T细胞或血清的被动转移对小鼠抵抗流产布鲁氏菌强毒株和减毒株的比较性保护作用
Comparative protection of mice against virulent and attenuated strains of Brucella abortus by passive transfer of immune T cells or serum.
作者信息
Araya L N, Winter A J
机构信息
Department of Veterinary Microbiology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
出版信息
Infect Immun. 1990 Jan;58(1):254-6. doi: 10.1128/iai.58.1.254-256.1990.
Abstract
Passively transferred immune serum provided significantly greater protection to BALB/c mice against attenuated Brucella abortus 19 than against virulent strain 2308, whether serum donors had been infected with strain 19 or 2308. In contrast, immune T cells conferred better protection upon recipients challenged with the homologous strain of B. abortus. It is hypothesized that strain 2308, but not strain 19, can survive in macrophages after opsonization and that epitopes which induce protective cell-mediated immunity may differ between strains 19 and 2308.
摘要
被动转移的免疫血清为BALB/c小鼠提供的针对减毒布鲁氏菌19的保护作用，显著强于针对强毒株2308的保护作用，无论血清供体是感染了19株还是2308株。相比之下，免疫T细胞对受到同源布鲁氏菌菌株攻击的受体提供了更好的保护。据推测，2308株而非19株在调理作用后可在巨噬细胞中存活，并且诱导保护性细胞介导免疫的表位在19株和2308株之间可能有所不同。
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