Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.
Analyst. 2011 Jan 21;136(2):401-6. doi: 10.1039/c0an00309c. Epub 2010 Nov 3.
Cytotrophoblast cell differentiation into syncytiotrophoblast cells is a complex and delicate process, and the mechanism needs a large number of further studies. Knockout of 14-3-3τ expression and some further investigations were performed in the syncytiotrophoblast cell formation with RNA interference (RNAi) technology. The study found that the 14-3-3τ expression level with the formation of syncytiotrophoblast cells increased. Hypoxia inhibited the formation of syncytiotrophoblast cells where 14-3-3τ expression level decreased. RNAi reduced 14-3-3τ expression, and reduced the formation of syncytiotrophoblast cells. So that 14-3-3τ is not only involved in the cell regulation, but also in the formation of syncytiotrophoblast cells. 14-3-3τ is an important regulatory factor which inhibits the formation of hypoxia.
滋养细胞向合体滋养层细胞的分化是一个复杂而微妙的过程，其机制需要大量进一步的研究。利用 RNA 干扰（RNAi）技术在合胞体滋养层细胞形成过程中敲除 14-3-3τ 的表达并进行了一些进一步的研究。研究发现，14-3-3τ 的表达水平随合胞体滋养层细胞的形成而增加。缺氧抑制合胞体滋养层细胞的形成，导致 14-3-3τ 表达水平下降。RNAi 降低了 14-3-3τ 的表达，减少了合胞体滋养层细胞的形成。因此，14-3-3τ 不仅参与细胞调节，还参与合胞体滋养层细胞的形成。14-3-3τ 是抑制缺氧形成的重要调节因子。
