Cloonan Nicole, Waddell Nic, Grimmond Sean M
The University of Queensland, Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, 306 Carmody Road, St Lucia, QLD 4072, Australia.
IDrugs. 2010 Nov;13(11):778-81.
Next-generation sequencing is revolutionizing the way in which genomic-scale biological research is performed, and its effects are beginning to be translated medically. Large-scale international collaborations for the comprehensive sequencing of the genome, epigenome, and transcriptomes of cancers and corresponding 'normal' (germ-line) DNA are heralding the start of personalized medical genomics. The promise of eliminating conjecture when determining treatment approaches is certainly appealing for both patients and clinicians; however, several major issues must be resolved before next-generation sequencing will be adopted as a routine clinical tool for patients. This feature review explores the clinical potential and challenges of studying cancer genomes for personalized medical genomics.
新一代测序正在彻底改变基因组规模生物学研究的开展方式，其影响正开始在医学领域得到应用。针对癌症及相应“正常”（种系）DNA的基因组、表观基因组和转录组进行全面测序的大规模国际合作，正预示着个性化医学基因组学的开端。在确定治疗方法时消除猜测的前景，对患者和临床医生而言无疑都很有吸引力；然而，在新一代测序被用作患者的常规临床工具之前，必须解决几个主要问题。这篇专题综述探讨了为实现个性化医学基因组学而研究癌症基因组的临床潜力和挑战。
