Department of Maternal-Fetal Medicine (Institut Clinic de Ginecologia, Obstetricia i Neonatologia), Fetal and Perinatal Medicine Research Group (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Hospital Clinic, University of Barcelona, Barcelona, Spain.
Ultrasound Obstet Gynecol. 2011 Jan;37(1):57-64. doi: 10.1002/uog.8870.
To construct gestational age (GA)- and estimated fetal weight (EFW)-adjusted reference ranges for tissue Doppler cardiac function parameters from 24 to 41 weeks' gestation.
This was a prospective cross-sectional observational study involving 213 singleton pregnancies between 24 and 41 weeks' gestation. Myocardial peak velocities and myocardial performance index (MPI') were measured by tissue Doppler ultrasonography (values indicated by 'prime') in the left and right annulus and interventricular septum. Left and right atrioventricular parameters were also measured by conventional Doppler and ratios between the values found by the two methods calculated. Regression analysis was used to determine GA- and EFW-adjusted reference ranges and to construct nomograms for tissue Doppler parameters.
All myocardial peak velocities, left and right E'/A' and left MPI' showed a progressive increase with GA. In contrast, left and right E/E' showed a progressive decline. Septal E'/A', and right and septal MPI' remained constant. Myocardial peak velocities showed a progressive increase with increasing fetal weight.
Normal data of fetal myocardial peak velocities, their ratios and MPI' by tissue Doppler adjusted by GA and EFW are provided. The reported reference values may be useful in research or clinical studies and can be used in fetuses with intrauterine growth restriction.
构建 24 至 41 孕周胎儿组织多普勒心脏功能参数的胎龄（GA）和估计胎儿体重（EFW）校正参考范围。
这是一项前瞻性的横断面观察性研究，涉及 213 例 24 至 41 孕周的单胎妊娠。通过组织多普勒超声测量左、右心环和室间隔心肌峰值速度和心肌做功指数（MPI'）（带撇号的值）。还通过常规多普勒测量左、右房室参数，并计算两种方法之间的比值。回归分析用于确定 GA 和 EFW 校正的参考范围，并构建组织多普勒参数的列线图。
所有心肌峰值速度、左、右 E'/A'和左 MPI'均随 GA 逐渐增加。相比之下，左、右 E/E'逐渐下降。室间隔 E'/A'和右、室间隔 MPI'保持不变。心肌峰值速度随胎儿体重增加而逐渐增加。
提供了胎儿心肌峰值速度、其比值和组织多普勒 MPI'的 GA 和 EFW 校正的正常数据。报告的参考值可用于研究或临床研究，并可用于宫内生长受限的胎儿。
