Huang Jin-Jun, Liu Da-Lie, Chen Bing, Wang Jin-Huang
Department of Plastic Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Zhonghua Zheng Xing Wai Ke Za Zhi. 2010 Jul;26(4):280-5.
To investigate the effect of Botulinum toxin type A (Botox) injection into the masseter muscle on mandibular development in rats.
12 28-day-old Wistar rats were divided into two groups as Botox group (n= 6) and control group (n = 6) which received anesthesia only. In Botox group, Botox was injected into the right masseter muscle, while only sterile saline into the left muscle. When the rats were 75-day-old, CT scan and 3D reconstruction were performed for cephalometry. The masseter muscles at both sides were weighed. Histologic study of masseter muscle and mandible was also performed.
The weight of right masseter muscle was (0.4575 +/- 0.0940) g in Botox group, and (0.8899 +/- 0.1030) g in control group (< 0.05). The mandibular height II and III was (10.8 +/- 0.8) mm and (9.5 +/- 0.6) mm in Botox group and (12.5 +/- 0.6) mm and (10.7 +/- 0.4) mm in control group, respectively (P < 0.05). The intergonial distance was (11.6 +/- 0.6) mm and (12.4 +/- 0. 6) mm in Botox and control group, respectively (P > 0.05).
When the rats receive Botox injection into the masseter muscle at young age, the grown-up rats have a decreased mandibular height, but the mandibular length and intergonial distance are not affected.
探讨A型肉毒杆菌毒素（保妥适）注射咬肌对大鼠下颌骨发育的影响。
将12只28日龄的Wistar大鼠分为两组，即保妥适组（n = 6）和仅接受麻醉的对照组（n = 6）。保妥适组将保妥适注射到右侧咬肌，而左侧肌肉仅注射无菌生理盐水。当大鼠75日龄时，进行CT扫描和三维重建以进行头颅测量。称量双侧咬肌重量。还对咬肌和下颌骨进行了组织学研究。
保妥适组右侧咬肌重量为（0.4575±0.0940）g，对照组为（0.8899±0.1030）g（P<0.05）。保妥适组下颌骨高度II和III分别为（10.8±0.8）mm和（9.5±0.6）mm，对照组分别为（12.5±0.6）mm和（10.7±0.4）mm（P<0.05）。保妥适组和对照组的下颌角间距离分别为（1
