Li Wei, Meng Xuemei
School of Dentistry, Tianjin Medical University, Tianjin 300070, PR China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2010 Oct;24(10):1249-52.
To introduce the cells and cell-transplantation methods for periodontal tissue engineering.
Recent literature about application of cell-based therapy in periodontal tissue engineering was extensively reviewed, the cells and cell-transplantation methods were investigated.
Mesenchymal stem cells were important cell resources for periodontal tissue engineering, among which periodontal ligament stem cells were preferred. Bone marrow mesenchymal stem cells had several disadvantages in clinical application, and adipose-derived stem cells might be a promising alternative; different transplantation methods could all promote periodontal regeneration to some extent. Single-cell suspension injection could only promote a little gingival regeneration, and tissue engineered scaffolds still needed some improvement to be used in periodontal regeneration, while cell sheet technique, with great cell loading ability and no need of scaffolds, could promote regeneration of cementum, periodontal ligament, and alveolar bone under different conditions.
Multipotent stem cells are fit to be used in periodontal tissue engineering; improvement of cell-transplantation methods will further promote periodontal regeneration.
介绍牙周组织工程的细胞及细胞移植方法。
广泛回顾近期基于细胞治疗在牙周组织工程中应用的文献，研究细胞及细胞移植方法。
间充质干细胞是牙周组织工程重要的细胞来源，其中牙周膜干细胞为首选。骨髓间充质干细胞在临床应用中有诸多缺点，脂肪来源干细胞可能是有前景的替代选择；不同移植方法均能在一定程度上促进牙周再生。单细胞悬液注射仅能促进少量牙龈再生，组织工程支架在牙周再生应用中仍需改进，而细胞片技术具有高细胞负载能力且无需支架，能在不同条件下促进牙骨质、牙周膜及牙槽骨再生。
多能干细胞适用于牙周组织工程；细胞移植方法的改进将进一步促进牙周再生。
