Ackrill A M, Blair G E
Department of Biochemistry, University of Leeds, United Kingdom.
Virology. 1990 Jan;174(1):325-8. doi: 10.1016/0042-6822(90)90084-5.
Interferon-gamma (IFN gamma) treatment of cells expressing the Ad12 E1A oncogene results in an increase in MHC class I antigen expression. The effect of IFN gamma upon both the steady-state level of class I mRNA and the in vitro rate of initiation of transcription of class I genes was studied in a rat cell line containing the Ad12 E1A gene. Results obtained showed a marked increase in steady-state level of cytoplasmic class I mRNA; however, a concomitant increase in the rate of transcription of class I genes was not observed. In contrast IFN gamma was shown to markedly increase the rate of transcription of class I genes in primary baby rat kidney cells.
用干扰素-γ（IFNγ）处理表达腺病毒12型E1A癌基因的细胞，会导致MHC I类抗原表达增加。在含有腺病毒12型E1A基因的大鼠细胞系中，研究了IFNγ对I类mRNA稳态水平和I类基因体外转录起始速率的影响。所得结果显示，细胞质I类mRNA的稳态水平显著增加；然而，未观察到I类基因转录速率随之增加。相比之下，IFNγ被证明可显著提高原代新生大鼠肾细胞中I类基因的转录速率。
