Sowmya R, Maruthy K N, Gupta Rani
Department of Physiology, St. John's Medical College, Bangalore 560 034.
Indian J Physiol Pharmacol. 2010 Jan-Mar;54(1):37-44.
The objective of this study was to assess blood pressure and autonomic activity during rest and recovery in young adult normotensives offsprings of hypertensives. A total of 49 healthy normotensive males with BMI of 18.5-24.9 kg/m2 chosen for the study and classified into two groups based on their parental history of hypertension underwent a sub maximal cycle ergometry exercise test. ECG and heart rate were recorded at baseline, during the exercise test and during recovery period of ten minutes while blood pressure was recorded at baseline and during recovery. Spectral analysis of HRV was performed. The basal systolic blood pressure and the recovery systolic blood pressures at the 1st and 3rd minute of recovery after exercise test were significantly higher in the study group than the control group. The basal LFnu and LF/HF ratio were significantly higher while the basal HFnu was significantly lower in the study group than the control group. A difference in basal systolic blood pressure, a higher LFnu and a lower HFnu found in offspring of hypertensive parents may be an early marker of cardiovascular change in subjects with a genetic predisposition to hypertension.
本研究的目的是评估高血压患者年轻成年正常血压后代在休息和恢复期间的血压及自主神经活动。共有49名BMI为18.5 - 24.9kg/m²的健康正常血压男性被选入本研究，并根据其父母的高血压病史分为两组，进行次极量蹬车运动试验。在基线、运动试验期间及十分钟恢复期记录心电图和心率，同时在基线和恢复期记录血压。进行心率变异性的频谱分析。运动试验后恢复第1分钟和第3分钟时，研究组的基础收缩压及恢复收缩压显著高于对照组。研究组的基础低频功率标准化值（LFnu）和低频/高频比值（LF/HF）显著更高，而基础高频功率标准化值（HFnu）显著更低。在高血压父母的后代中发现的基础收缩压差异、较高的LFnu和较低的HFnu可能是有高血压遗传易感性受试者心血管变化的早期标志物。
