Bond V, Franks B D, Tearney R J, Wood B, Melendez M A, Johnson L, Iyriboz Y, Bassett D R
Department of Kinesiology, Louisiana State University, Baton Rouge.
J Hypertens. 1994 Mar;12(3):285-90.
To study exercise blood pressure response in association with exercising muscle maximal vasodilatory capacity in normotensives with a positive and negative family history of hypertension.
Twenty-eight normotensive healthy subjects were recruited. Of these, two females and 13 males had a positive, and three females and 10 males had a negative, family history of hypertension.
Both groups of subjects rode a bicycle ergometer while systolic blood pressure, diastolic blood pressure and heart rate were measured at 30%, 60% and peak oxygen uptake rate. The vasodilatory capacity was examined in the lower leg by measuring the minimal vascular resistance during peak reactive hyperemia after 10 min arterial occlusion.
Age, body weight, resting blood pressure, peak oxygen uptake rate and casual lower leg vascular resistance were not significantly different between the two groups of subjects. Significantly higher exercise systolic blood pressure (9%) and diastolic blood pressure (9%) were seen in the subjects with positive family history of hypertension compared with the subjects with negative family history of hypertension. Exercise heart rate was significantly higher in the subjects with negative than in those with positive family history of hypertension. The vascular resistance at peak vasodilation was 22% higher in the subjects with positive than in the subjects with negative family history of hypertension.
This study demonstrates that the dynamic exercise blood pressure is exaggerated and skeletal muscle vasodilatory capacity is limited in normotensives with genetic risk of hypertension. This suggests that the higher pressor response to physical stress that is found in normotensives with a family history of hypertension may be attributed to the resistance vessels in the exercising muscle.
研究有高血压家族史阳性和阴性的正常血压者运动血压反应与运动肌肉最大血管舒张能力之间的关系。
招募了28名血压正常的健康受试者。其中，2名女性和13名男性有高血压家族史阳性，3名女性和10名男性有高血压家族史阴性。
两组受试者均骑动感单车，在摄氧量为30%、60%和峰值时测量收缩压、舒张压和心率。通过测量10分钟动脉闭塞后峰值反应性充血期间的最小血管阻力来检测小腿的血管舒张能力。
两组受试者的年龄、体重、静息血压、峰值摄氧量和小腿随意血管阻力无显著差异。有高血压家族史阳性的受试者运动收缩压（9%）和舒张压（9%）显著高于有高血压家族史阴性的受试者。有高血压家族史阴性的受试者运动心率显著高于有高血压家族史阳性的受试者。有高血压家族史阳性的受试者血管舒张峰值时的血管阻力比有高血压家族史阴性的受试者高22%。
本研究表明，有高血压遗传风险的正常血压者动态运动血压升高，骨骼肌血管舒张能力受限。这表明，有高血压家族史的正常血压者对身体应激的升压反应较高可能归因于运动肌肉中的阻力血管。
