Ravikumar S, Thajuddin N, Suganthi P, Inbaneson S Jacob, Vinodkumar T
School of Marine Sciences, Centre for Marine Pharmacology, Alagappa University, Thondi Campus 623409, India.
J Environ Biol. 2010 May;31(3):387-9.
Study of marine organisms for their bioactive potential, being an important part of marine ecosystem, has picked up the rhythm in recent years with the growing recognition of their importance in human life. Investigation was carried out to isolate 32 strains of endo and epiphytic bacteria in 2 seagrass species viz., Syringodium isoetifolium and Cymodocea serrulata. Morphologically different bacterial strains were tested against 5 antibiotic resistant human bacterial pathogens, of which 10 associated bacteria shown inhibitory activity against one or more bacterial pathogens. Minimum inhibitory concentration (MIC) and Minimum bacterial concentration (MBC) determination with extracellular bioactive compounds from the associated bacteria reveals that, the strain ENC 5 showed inhibitory activity against all the bacterial pathogens with the maximum sensitivity against Pseudomonas aeruginosa at the MIC value of 500 microg ml(-1).
对海洋生物的生物活性潜力进行研究，海洋生物作为海洋生态系统的重要组成部分，近年来随着人们对其在人类生活中重要性的认识不断提高，相关研究已加快了节奏。开展了一项调查，以从2种海草物种，即异叶海菖蒲和锯齿泰来藻中分离出32株内生和附生细菌。对形态不同的细菌菌株针对5种抗生素抗性人类细菌病原体进行了测试，其中10株相关细菌对一种或多种细菌病原体表现出抑制活性。对来自相关细菌的细胞外生物活性化合物进行最低抑菌浓度（MIC）和最低杀菌浓度（MBC）测定表明，菌株ENC 5对所有细菌病原体均表现出抑制活性，对铜绿假单胞菌的敏感性最高，MIC值为500微克/毫升（-1）。
