锂对豚鼠脑内去甲肾上腺素和多巴胺敏感的环磷酸腺苷积累的差异作用。
The differential effect of lithium on noradrenaline- and dopamine-sensitive accumulation of cyclic AMP in guinea pig brain.
作者信息
Reches A, Ebstein R P, Belmaker R H
出版信息
Psychopharmacology (Berl). 1978 Jul 6;58(2):213-6. doi: 10.1007/BF00426910.
PMID:210477
Abstract
Lithium (Li) in its narrow therapeutic concentration range was found to inhibit only the noradrenaline- and not the dopamine-sensitive accumulation of cyclic AMP in guinea pig brain. The results suggest a pharmacological distinction between the anti-schizophrenic drugs that inhibit dopamine-sensitive cyclic AMP accumulation and Li, an antimanic agent that inhibits specifically only the noradrenaline-sensitive cyclic AMP accumulation.
摘要
在其狭窄的治疗浓度范围内，锂（Li）被发现仅抑制豚鼠脑中去甲肾上腺素敏感的环磷酸腺苷（cAMP）积累，而不抑制多巴胺敏感的cAMP积累。这些结果表明，抑制多巴胺敏感的cAMP积累的抗精神分裂症药物与锂（一种仅特异性抑制去甲肾上腺素敏感的cAMP积累的抗躁狂剂）之间存在药理学差异。
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