Saatçi Yaşar Ayşe, Bilen Emine, Yüksel Isa Oner, Ipek Göktürk, Kurt Mustafa, Ipek Emrah, Bilge Mehmet
Department of Cardiology, Atatürk Training and Research Hospital, Ankara, Turkey.
Anadolu Kardiyol Derg. 2010 Dec;10(6):514-8. doi: 10.5152/akd.2010.168. Epub 2010 Nov 4.
We aimed to evaluate coronary blood flow by means of the TIMI (Thrombolysis in Myocardial Infarction) frame count in patients with idiopathic dilated cardiomyopathy who had angiographically proven normal coronary arteries and compare the results with those of healthy subjects.
This retrospective study included 62 patients with idiopathic dilated cardiomyopathy (34 men, 28 women; mean age 59.7 ± 10.6 years) and 62 control subjects without dilated cardiomyopathy (28 men, 34 women; mean age 56.6 ± 9.8 years). All patients and control subjects had angiographically proven normal coronary arteries. Dilated cardiomyopathy patients had a left ventricular ejection fraction =45%. The TIMI frame count was determined for each major coronary artery in each patient. Statistical analysis was performed using Student's t test, Chi-square test and Pearson correlation analysis.
The TIMI frame counts for each major epicardial coronary artery were found to be significantly higher in patients with idiopathic dilated cardiomyopathy compared to control subjects (corrected TIMI frame count for left anterior descending coronary artery: 37.0 ± 12.5 vs 28.7 ± 11.6, respectively, p=0.001; left circumflex coronary artery: 37.7 ± 12.1 vs 31.0 ± 12.5, respectively, p=0.003; right coronary artery: 37.4 ± 12.6 vs 30.7 ± 11.6, respectively, p=0.003). Mean TIMI frame count had significant although weak positive correlation with left ventricular end-diastolic diameter (r=0.350, p=0.001) and left ventricular end-systolic diameter (r=0.358, p=0.001).
We have shown that patients with idiopathic dilated cardiomyopathy and angiographically normal coronary arteries have higher TIMI frame counts for all three coronary vessels, indicating impaired coronary blood flow, compared to control subjects without dilated cardiomyopathy.
我们旨在通过心肌梗死溶栓治疗（TIMI）帧数法评估冠状动脉造影显示冠状动脉正常的特发性扩张型心肌病患者的冠状动脉血流，并将结果与健康受试者进行比较。
这项回顾性研究纳入了62例特发性扩张型心肌病患者（34例男性，28例女性；平均年龄59.7±10.6岁）和62例无扩张型心肌病的对照受试者（28例男性，34例女性；平均年龄56.6±9.8岁）。所有患者和对照受试者的冠状动脉造影均显示正常。扩张型心肌病患者的左心室射血分数≤45%。测定每位患者各主要冠状动脉的TIMI帧数。采用学生t检验、卡方检验和Pearson相关分析进行统计分析。
与对照受试者相比，特发性扩张型心肌病患者各主要心外膜冠状动脉的TIMI帧数显著更高（左前降支冠状动脉校正TIMI帧数：分别为37.0±12.5和28.7±11.6，p=0.001；左旋支冠状动脉：分别为37.7±12.1和31.0±12.5，p=0.003；右冠状动脉：分别为37.4±12.6和30.7±11.6，p=0.003）。平均TIMI帧数与左心室舒张末期内径（r=0.350，p=0.001）和左心室收缩末期内径（r=0.358，p=0.001）呈显著但较弱的正相关。
我们已经表明，与无扩张型心肌病的对照受试者相比，冠状动脉造影正常的特发性扩张型心肌病患者的所有三支冠状动脉的TIMI帧数更高，表明冠状动脉血流受损。
