Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway.
Mol Cancer Res. 2010 Nov;8(11):1439-52. doi: 10.1158/1541-7786.MCR-10-0168. Epub 2010 Oct 13.
The fibroblast growth factor receptors (FGFR) play essential roles both during development and in the adult. Upon ligand binding, FGFRs induce intracellular signaling networks that tightly regulate key biological processes, such as cell proliferation, survival, migration, and differentiation. Deregulation of FGFR signaling can thus alter tissue homeostasis and has been associated with several developmental syndromes as well as with many types of cancer. In human cancer, FGFRs have been found to be deregulated by multiple mechanisms, including aberrant expression, mutations, chromosomal rearrangements, and amplifications. In this review, we will give an overview of the main FGFR alterations described in human cancer to date and discuss their contribution to cancer progression.
成纤维细胞生长因子受体（FGFR）在发育和成年期都发挥着重要作用。配体结合后，FGFR 诱导细胞内信号网络，这些信号网络紧密调节关键的生物过程，如细胞增殖、存活、迁移和分化。因此，FGFR 信号的失调会改变组织的平衡，并与几种发育综合征以及许多类型的癌症有关。在人类癌症中，已经发现 FGFR 通过多种机制失调，包括异常表达、突变、染色体重排和扩增。在这篇综述中，我们将概述迄今为止在人类癌症中描述的主要 FGFR 改变，并讨论它们对癌症进展的贡献。
