Hill S Y, Reyes R B
Psychopharmacology (Berl). 1978 Jul 19;58(3):229-33. doi: 10.1007/BF00427384.
Sleep parameters were monitored following (1) a single 2 g/kg oral dose of ethanol, (2) an oral dose of L-tryptophan (600 mg/kg), and (3) administration of both drugs simultaneously. Ethanol reduced REM and increased slow wave significantly. The effects of L-tryptophan were apparent only in the case of one parameter, REM latency. Administration of both drugs resulted in a significantly shorter REM latency than that observed for ethanol alone. Results are discussed in terms of possible changes in the biosynthesis of 5-HT.
(1) 单次口服2 g/kg乙醇剂量；(2) 口服L-色氨酸（600 mg/kg）剂量；(3) 同时给予两种药物。乙醇显著减少快速眼动睡眠（REM）并增加慢波睡眠。L-色氨酸的作用仅在一个参数即REM潜伏期方面明显。两种药物同时给药导致REM潜伏期明显短于单独给予乙醇时观察到的情况。根据5-羟色胺（5-HT）生物合成的可能变化对结果进行了讨论。
