Jesionowska H, Hemmings R, Guyda H J, Posner B I
McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada.
Fertil Steril. 1990 Jan;53(1):88-91. doi: 10.1016/s0015-0282(16)53221-x.
Recent in vitro studies implicate the ovary as an extra-hepatic source of insulin-like growth factors (IGFs) with production regulated by gonadotropins and local steroids. Because previous studies have failed to show any significant variations in IGF levels in peripheral blood during the menstrual cycle, we measured the concentrations of IGF-I, IGF-II, and insulin in ovarian and peripheral venous blood samples obtained simultaneously from nine women undergoing abdominal hysterectomy to obtain more detailed data on the ovarian contribution. A significant decreased ovarian gradient was found for IGF-II but not for IGF-I or insulin. Although there was no significant ovarian vein insulin gradient, insulin levels were higher in follicular than in luteal phase ovarian samples. These data suggest that IGF-II may be locally regulated by the ovary. Both insulin and IGFs may regulate ovarian function in vivo.
最近的体外研究表明，卵巢是胰岛素样生长因子（IGF）的肝外来源，其产生受促性腺激素和局部类固醇调节。由于先前的研究未能显示月经周期中外周血IGF水平有任何显著变化，我们测量了同时从9名接受腹部子宫切除术的女性身上采集的卵巢和外周静脉血样本中IGF-I、IGF-II和胰岛素的浓度，以获取有关卵巢贡献的更详细数据。发现IGF-II存在显著的卵巢梯度降低，但IGF-I或胰岛素没有。虽然没有显著的卵巢静脉胰岛素梯度，但卵泡期卵巢样本中的胰岛素水平高于黄体期。这些数据表明，IGF-II可能受卵巢局部调节。胰岛素和IGF都可能在体内调节卵巢功能。
