Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
J Immunol. 2010 Nov 15;185(10):5677-82. doi: 10.4049/jimmunol.1002156.
Flagellin is a potent activator of a broad range of cell types involved in innate and adaptive immunity. An increasing number of studies have demonstrated the effectiveness of flagellin as an adjuvant, as well as its ability to promote cytokine production by a range of innate cell types, trigger a generalized recruitment of T and B lymphocytes to secondary lymphoid sites, and activate TLR5(+)CD11c(+) cells and T lymphocytes in a manner that is distinct from cognate Ag recognition. The plasticity of flagellin has allowed for the generation of a range of flagellin-Ag fusion proteins that have proven to be effective vaccines in animal models. This review summarizes the state of our current understanding of the adjuvant effect of flagellin and addresses important areas of current and future research interest.
鞭毛蛋白是一种有效的激活剂，能够激活先天免疫和适应性免疫中涉及的广泛细胞类型。越来越多的研究表明，鞭毛蛋白具有佐剂作用，能够促进多种先天细胞类型产生细胞因子，引发 T 和 B 淋巴细胞向次级淋巴组织的广泛募集，并以不同于同源 Ag 识别的方式激活 TLR5(+)CD11c(+)细胞和 T 淋巴细胞。鞭毛蛋白的可塑性使得一系列鞭毛蛋白-抗原融合蛋白得以产生，这些融合蛋白已被证明在动物模型中是有效的疫苗。本文综述了我们目前对鞭毛蛋白佐剂作用的理解，并讨论了当前和未来研究的重要领域。
