细胞外基质衍生肽与心肌修复。
Extracellular matrix-derived peptides and myocardial repair.
机构信息
Cardiovascular Research Institute, University of California-San Francisco, CA, USA.
出版信息
Cell Adh Migr. 2011 Mar-Apr;5(2):111-3. doi: 10.4161/cam.5.2.13796. Epub 2011 Mar 1.
Abstract
Repairing cardiac tissue remains one of the most challenging goals in tissue engineering. Here, we discuss ways whereby we sought to treat myocardial infarctions using extracellular-matrix derived peptides. Using an ischemia/reperfusion myocardial infarction rodent model, we targeted these extracellular matrix-derived peptides to the myocardial infarct site and were able to induce angiogenesis and alter the negative remodeling seen after an acute myocardial infarction. Our results indicate a potentially new strategy for repairing damaged tissue.
摘要
修复心脏组织仍然是组织工程学中最具挑战性的目标之一。在这里，我们讨论了使用细胞外基质衍生肽治疗心肌梗死的方法。我们使用缺血/再灌注心肌梗死啮齿动物模型，将这些细胞外基质衍生肽靶向心肌梗死部位，能够诱导血管生成，并改变急性心肌梗死后的负性重构。我们的结果表明了一种修复受损组织的潜在新策略。
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