Bedaiwy Mohamed A, Falcone Tommaso
Department of Obstetrics-Gynecology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Clin Obstet Gynecol. 2010 Dec;53(4):797-803. doi: 10.1097/GRF.0b013e3181f97c94.
Several strategies have been developed in an attempt to preserve fertility in these women, including ovarian transplantation. The current protocols of ovarian transplantation require transplanting fresh or cryopreserved-thawed ovarian cortical strips in an orthotopic or heterotopic location. The main limitation of this approach is the limited longevity of graft function because of the posttransplantation ischemic injury. Whole ovary cryopreservation with its' vascular pedicle with subsequent transplantation with a vascular anastomosis is one experimental approach to minimize the effects of ischemic damage including whole ovary transplantation.
为了保留这些女性的生育能力,已经开发了几种策略,包括卵巢移植。目前的卵巢移植方案需要在原位或异位位置移植新鲜的或冷冻解冻的卵巢皮质条。这种方法的主要局限性是由于移植后的缺血性损伤,移植功能的寿命有限。带血管蒂的全卵巢冷冻保存,随后进行血管吻合移植,是一种尽量减少缺血损伤影响的实验方法,包括全卵巢移植。