Ramperti Nicolas, Anwar Mansoor, Renwick Laoise, Jackson Deirdre, Foley Sharon, McWilliams Stephen, Behan Caragh, Sutton Marie, Kinsella Anthony, Turner Niall, O'Callaghan Eadbhard
DETECT Service, Blackrock, Co Dublin, Ireland.
J Nerv Ment Dis. 2010 Nov;198(11):820-3. doi: 10.1097/NMD.0b013e3181f97c29.
Most studies of First Rank Symptoms (FRS) are based on cross-sectional inpatient samples of people with schizophrenia at various stages of illness. We sought to examine the prevalence of FRS in a representative sample of first episode psychosis patients and compare those with and without FRS clinically and in terms of duration of untreated illness. Information was gathered from 158 consecutive cases of first episode psychosis presenting in a defined geographical region through semi-structured interview tools. Of this sample, 40.5% of cases received a diagnosis of schizophrenia. The prevalence of FRS among the entire group was 52.5%. After controlling for multiple testing, no FRS contributed significantly to predicting a diagnosis of schizophrenia. There was no significant relationship between the duration of untreated illness and FRS.
大多数关于一级症状（FRS）的研究是基于处于疾病不同阶段的精神分裂症患者的横断面住院样本。我们试图在首发精神病患者的代表性样本中检测FRS的患病率，并在临床以及未治疗疾病持续时间方面比较有和没有FRS的患者。通过半结构化访谈工具，从在一个特定地理区域连续就诊的158例首发精神病病例中收集信息。在这个样本中，40.5%的病例被诊断为精神分裂症。整个组中FRS的患病率为52.5%。在控制多重检验后，没有任何FRS对预测精神分裂症诊断有显著贡献。未治疗疾病持续时间与FRS之间没有显著关系。
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