Romm Kristin Lie, Rossberg Jan Ivar, Berg Akiah Ottesen, Barrett Elizabeth Ann, Faerden Ann, Agartz Ingrid, Andreassen Ole A, Melle Ingrid
Department of Psychiatry, Oslo University Hospital, Ulleval, Oslo, Norway.
J Nerv Ment Dis. 2010 Jan;198(1):67-71. doi: 10.1097/NMD.0b013e3181c81fc0.
The aims of this study were to examine the prevalence and pattern of lifetime Diagnostic and Structural Manual of Mental Disorders (fourth version) major depressive episodes, and the relationship between patient characteristics and current severity of depressive symptoms in first episode psychosis patients (FEPP). A total of 122 FEPP from the ongoing longitudinal thematically organized psychosis research study were included at first treatment. A total of 58 patients (48%) had experienced one or more major depressive episodes; 21 (17%) before onset of psychosis and 37 (30%) during or after onset of psychosis. Poor premorbid childhood adjustment, substance abuse, and excitative symptoms at start of treatment were statistically significant associated with higher current severity of depressive symptoms. Alcohol use was significantly associated with current severity of depression in men, while excitative symptoms were associated in women. Thus depressive symptoms are frequent among FEPP, with indications of gender specific differences in patient characteristics that might imply different approaches to treatment.
本研究的目的是调查首次发作精神病患者（FEPP）一生中《精神疾病诊断与统计手册》（第四版）重度抑郁发作的患病率及模式，以及患者特征与当前抑郁症状严重程度之间的关系。首次治疗时纳入了正在进行的纵向主题性精神病研究中的122例FEPP。共有58例患者（48%）经历过一次或多次重度抑郁发作；21例（17%）在精神病发作前，37例（30%）在精神病发作期间或之后。病前儿童期适应不良、物质滥用以及治疗开始时的激越症状与当前较高的抑郁症状严重程度在统计学上显著相关。男性饮酒与当前抑郁严重程度显著相关，而女性则与激越症状相关。因此，抑郁症状在FEPP中很常见，患者特征存在性别差异，这可能意味着治疗方法有所不同。
