生长抑素类似物和17-α-双氢马萘雌酮对大鼠脑阿片受体的影响。
Effect of somatostatin analogues and 17-alpha-dihydroequilin on rat brain opiate receptors.
作者信息
Pugsley T A, Lippmann W
出版信息
Res Commun Chem Pathol Pharmacol. 1978 Jul;21(1):153-6.
PMID:210485
Abstract
Two somatostatin analogues (SA) and 17-alpha-dihydroequilin (E) inhibited the stereospecific binding of 3H-naloxone in vitro to rat brain opiate receptors in the absence of sodium. The addition of sodium indicated the SA to be greater or similar in potency to somatostatin as opiate agonists and E to be an opiate antagonist. The results indicate that SA and certain steroids may affect endorphin containing neurons.
摘要
两种生长抑素类似物（SA）和17-α-二氢马萘雌酮（E）在无钠条件下，于体外抑制了³H-纳洛酮与大鼠脑阿片受体的立体特异性结合。加入钠后表明，SA作为阿片激动剂，其效力比生长抑素更强或与之相似，而E则是一种阿片拮抗剂。结果表明，SA和某些类固醇可能会影响含内啡肽的神经元。
Zotero 插件