Rubinow D R, Post R M, Gold P W, Ballenger J C, Reichlin S
Psychopharmacology (Berl). 1985;85(2):210-3. doi: 10.1007/BF00428416.
This paper reports the reduction of the concentration of the neuropeptide somatostatin in the CSF of patients with affective illness during treatment with the anticonvulsant carbamazepine. None of the other psychotropic agents used in this study similarly affected CSF somatostatin, although zimelidine appeared to increase CSF somatostatin in a small number of patients. The potential mechanism and significance of the effects of carbamazepine on CSF somatostatin are discussed in relation to the psychotropic, anticonvulsant, and analgesic properties of carbamazepine.
本文报道了情感性疾病患者在使用抗惊厥药物卡马西平治疗期间，其脑脊液中神经肽生长抑素浓度降低。本研究中使用的其他精神药物均未对脑脊液生长抑素产生类似影响，尽管齐美利定在少数患者中似乎会使脑脊液生长抑素增加。结合卡马西平的精神药理、抗惊厥和镇痛特性，讨论了卡马西平对脑脊液生长抑素影响的潜在机制及意义。
