雌性大鼠对可卡因的血氧水平依赖（BOLD）信号反应随性接受能力而变化。
BOLD signal response to cocaine varies with sexual receptivity in female rats.
作者信息
Febo Marcelo, Segarra Annabell C, Stolberg Tara L, Ferris Craig F
机构信息
Center for Translational NeuroImaging, Northeastern University, Boston, Massachusetts, USA.
出版信息
Neuroreport. 2011 Jan 5;22(1):19-22. doi: 10.1097/WNR.0b013e3283416f81.
Abstract
Blood oxygen level dependent MRI was used to test whether cocaine-stimulated mesolimbic activity varied with sexual receptivity. Rats were randomly screened for lordotic responses and were then imaged for their responses to centrally administered cocaine. We observed that female rats expressing no lordosis showed a greater activation of mesolimbic and nigrostriatal structures than lordotic female rats. Our data suggest that the differential sensitivity to cocaine occurs not only as a result of hormonal changes of the estrous cycle, but also in association with changes in sexual receptivity.
摘要
采用血氧水平依赖性功能磁共振成像来测试可卡因刺激引起的中脑边缘系统活动是否随性接受度而变化。对大鼠的脊柱前凸反应进行随机筛选，然后对它们对中枢给予可卡因的反应进行成像。我们观察到，未表现出脊柱前凸的雌性大鼠比有脊柱前凸的雌性大鼠的中脑边缘系统和黑质纹状体结构激活程度更高。我们的数据表明，对可卡因的敏感性差异不仅是发情周期激素变化的结果，还与性接受度的变化有关。
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