Bio-X Center and Affiliated Changning Mental Health Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
PLoS One. 2010 Oct 27;5(10):e13662. doi: 10.1371/journal.pone.0013662.
Myelin transcription factor 1-like (MYT1L) is a member of the myelin transcription factor 1 (MYT1) gene family, and the neural specific, zinc-finger-containing, DNA-binding protein that it encodes plays a role in the development of the nervous system. On the basis of a recent copy number variation (CNV) study showing that this gene is disrupted in mental disorder patients, we investigated whether MYT1L also plays a role in MDD.
In this study, 8 SNPs were analyzed in 1139 MDD patients and 1140 controls of Chinese Han origin.
Statistically significant differences were noted between cases and controls for rs3748989 (allele: permutated p = 0.0079, corrected p = 0.0048, genotype: corrected p = 0.0204). A haplotype of rs1617213 and rs6759709 G-C was also significant (permutated p = 0.00007).
Our results indicate that MYT1L may be a potential risk gene for MDD in the Chinese Han population.
髓鞘转录因子 1 样（MYT1L）是髓鞘转录因子 1（MYT1）基因家族的一员，其编码的神经特异性、含锌指的 DNA 结合蛋白在神经系统发育中发挥作用。基于最近一项拷贝数变异（CNV）研究表明，该基因在精神障碍患者中被破坏，我们研究了 MYT1L 是否也与 MDD 有关。
本研究分析了 1139 例中国汉族 MDD 患者和 1140 例对照的 8 个 SNP。
病例组和对照组在 rs3748989（等位基因：置换 p=0.0079，校正后 p=0.0048，基因型：校正后 p=0.0204）存在统计学差异。rs1617213 和 rs6759709G-C 单体型也具有显著性（置换后 p=0.00007）。
我们的结果表明，在中国汉族人群中，MYT1L 可能是 MDD 的一个潜在风险基因。
