[南海红树林内生真菌BL321的次生代谢产物]
[Secondary metabolites of mangrove endophytic fungus BL321 in the South China Sea].
作者信息
Song Yong-Xiang, Ma Huan-Ge, Wang Jun, Liu Lan, She Zhi-Gang, Lin Yong-Cheng
机构信息
School of Chemicsty and Chemical Engineering, Sun Yat-sen University/Key Laboratory of Function Molecule from Marine Microorganism Department of Education of Guangdong Provience, Guangzhou 510275, China.
出版信息
Zhong Yao Cai. 2010 Jun;33(6):901-3.
OBJECTIVE
To study the secondary metabolites of mangrove endophytic fungus BL321.
METHODS
The compounds were isolated by chromatographic technique. The structures were identified by comprehensive physico-chemical properties and spectral methods.
RESULTS
Five compounds were isolated and identified as 3,4a-dimethyl-2-oxo-2,4,4a,5,6,7-hexahydronaphtho[2,3-b]furan-5-carboxylic acid(1), cytochalasin C(2), cytochalasin D(3), 19,20-epoxycytochalasin C(4), ergosterol(5).
CONCLUSION
Compound 1 is isolated from nature for the first time. Further more, several kinds of strong bioactive compounds were islolate from this fungus indicate that it may develop to be medical source microorganism.
目的
研究红树林内生真菌BL321的次生代谢产物。
方法
采用色谱技术分离化合物，通过综合物理化学性质和光谱方法鉴定结构。
结果
分离并鉴定出5种化合物，分别为3,4a-二甲基-2-氧代-2,4,4a,5,6,7-六氢萘并[2,3-b]呋喃-5-羧酸（1）、细胞松弛素C（2）、细胞松弛素D（3）、19,20-环氧细胞松弛素C（4）、麦角甾醇（5）。
结论
化合物1首次从自然界中分离得到。此外，从该真菌中分离出几种具有强生物活性的化合物，表明它可能发展成为药用微生物资源。
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