Chen Yiguang, Shao Changlun, Huang Zhongjing, Zhang Ying, Cai Xiaoling, She Zhigang, Zhou Shining, Lin Yongcheng
School of Chemistry and Chemical Engineering, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510275, PR China.
Magn Reson Chem. 2009 Jan;47(1):92-5. doi: 10.1002/mrc.2346.
The structure elucidations and complete (1)H and (13)C NMR assignments are reported for two new natural products: 3-benzylidene-8,8a-dihydroxy-2-methyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione(1) and 4-hydroxy-6-(hydroxy-phenyl-methyl)-N-(3-methyl-butyryl)-nicotinamide (2). Both of these secondary metabolites were isolated from the fermentation medium of a Mangrove endophytic fungus. High resolution electron impact mass spectrometry (HREIMS), FT-IR Spectroscopy and NMR experiments including gCOSY, gHMQC, gHMBC and NOE were used for determination of the structures and assignments of the amide alkaloids.
报道了两种新天然产物的结构解析以及完整的氢谱（¹H）和碳谱（¹³C）核磁共振归属：3-亚苄基-8,8a-二羟基-2-甲基-六氢-吡咯并[1,2-a]吡嗪-1,4-二酮（1）和4-羟基-6-（羟基苯甲基）-N-（3-甲基丁酰基）-烟酰胺（2）。这两种次生代谢产物均从一种红树林内生真菌的发酵培养基中分离得到。采用高分辨率电子轰击质谱（HREIMS）、傅里叶变换红外光谱（FT-IR）以及包括gCOSY、gHMQC、gHMBC和NOE在内的核磁共振实验来确定这些酰胺生物碱的结构和归属。
