Parker J A, Nagel J S, Drum D E, Tumeh S S, Goldhaber S Z
Department of Radiology, Beth Israel Hospital, Boston, MA 02215.
Radiology. 1990 Feb;174(2):483-6. doi: 10.1148/radiology.174.2.2104990.
Lung scan data from a series of 45 patients receiving thrombolytic therapy were reviewed to determine if any pattern on the pretherapy perfusion lung scans could be identified that predicted response to therapy. A segmental appearance on the pretherapy scans (complete or nearly complete absence of perfusion in a whole segment or a very large subsegment) was correlated with the amount of improvement in perfusion on lung scans obtained 24 hours after the start of thrombolytic therapy. As a group, patients with a segmental appearance on the pretherapy lung scans had more improvement in the perfusion reduction score than patients with a nonsegmental appearance (P less than .005). However, the correlation between segmental appearance and a favorable response to thrombolytic therapy was not strong enough to allow use of this appearance in the selection of patients for therapy.
回顾了45例接受溶栓治疗患者的肺部扫描数据，以确定治疗前灌注肺扫描上是否存在可预测治疗反应的任何模式。治疗前扫描上的节段性表现（整个节段或非常大的亚节段完全或几乎完全无灌注）与溶栓治疗开始后24小时获得的肺部扫描灌注改善量相关。作为一个整体，治疗前肺部扫描有节段性表现的患者在灌注减少评分方面比无节段性表现的患者有更大改善（P小于0.005）。然而，节段性表现与溶栓治疗良好反应之间的相关性不够强，不足以在选择治疗患者时使用这种表现。
