Institut für Organische Chemie und Biochemie, Freiburg Institute for Advanced Studies (FRIAS), Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, 79104, Freiburg, Germany.
Org Lett. 2010 Dec 3;12(23):5498-501. doi: 10.1021/ol102365e. Epub 2010 Nov 4.
The selective intermolecular anti-Markovnikov addition of carboxylic acids to terminal alkynes yielding valuable Z-enol esters has been achieved for the first time under rhodium-catalyzed conditions. The catalyst system is applicable to a broad substrate scope and displays a wide functional group tolerance.
首次在铑催化条件下实现了羧酸与末端炔烃的选择性分子间反马氏加成，生成有价值的 Z-烯醇酯。该催化剂体系适用于广泛的底物范围，并具有广泛的官能团容忍度。
