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纳米结构引发质谱代谢物分析和成像。

Nanostructure-initiator mass spectrometry metabolite analysis and imaging.

机构信息

Center for Metabolomics and Mass Spectrometry, Department of Chemistry, The Scripps Research Institute.

出版信息

Anal Chem. 2011 Jan 1;83(1):2-7. doi: 10.1021/ac101565f. Epub 2010 Nov 4.

DOI:10.1021/ac101565f
PMID:21049956
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3012143/
Abstract

Nanostructure-Initiator Mass Spectrometry (NIMS) is a matrix-free desorption/ionization approach that is particularly well-suited for unbiased (untargeted) metabolomics. An overview of the NIMS technology and its application in the detection of biofluid and tissue metabolites are presented. (To listen to a podcast about this feature, please go to the Analytical Chemistry multimedia page at pubs.acs.org/page/ancham/audio/index.html .).

摘要

纳米结构引发质谱法 (NIMS) 是一种无基质解吸/电离方法，特别适合于无偏向（非靶向）代谢组学。本文概述了 NIMS 技术及其在生物流体和组织代谢物检测中的应用。（要收听有关此功能的播客，请访问 pubs.acs.org/page/ancham/audio/index.html 的分析化学多媒体页面。）。

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本文引用的文献

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Nanostructure-initiator mass spectrometry (NIMS) imaging of brain cholesterol metabolites in Smith-Lemli-Opitz syndrome.纳米结构引发质谱（NIMS）成像在 Smith-Lemli-Opitz 综合征中的脑胆固醇代谢产物。
Neuroscience. 2010 Oct 27;170(3):858-64. doi: 10.1016/j.neuroscience.2010.07.038. Epub 2010 Jul 27.
2
Rapid screening of fatty acids using nanostructure-initiator mass spectrometry.利用纳米结构引发质谱法快速筛选脂肪酸。
Anal Chem. 2010 May 1;82(9):3751-5. doi: 10.1021/ac100159y.
3
Matrix vapor deposition/recrystallization and dedicated spray preparation for high-resolution scanning microprobe matrix-assisted laser desorption/ionization imaging mass spectrometry (SMALDI-MS) of tissue and single cells.基质气相沉积/重结晶和专用喷雾制备用于组织和单细胞的高分辨率扫描微探针基质辅助激光解吸/电离成像质谱（SMALDI-MS）。
Rapid Commun Mass Spectrom. 2010 Feb;24(3):355-64. doi: 10.1002/rcm.4401.
4
Exploring disease through metabolomics.通过代谢组学探索疾病。
ACS Chem Biol. 2010 Jan 15;5(1):91-103. doi: 10.1021/cb900271r.
5
Detection of carbohydrates and steroids by cation-enhanced nanostructure-initiator mass spectrometry (NIMS) for biofluid analysis and tissue imaging.通过阳离子增强纳米结构引发质谱（NIMS）检测生物流体和组织中的碳水化合物和类固醇。
Anal Chem. 2010 Jan 1;82(1):121-8. doi: 10.1021/ac9014353.
6
In situ metabolic profiling of single cells by laser ablation electrospray ionization mass spectrometry.激光微区电喷雾电离质谱法对单细胞的原位代谢组学分析。
Anal Chem. 2009 Oct 15;81(20):8265-71. doi: 10.1021/ac901525g.
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Nanostructure initiator mass spectrometry: tissue imaging and direct biofluid analysis.纳米结构引发剂质谱法：组织成像与直接生物流体分析
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Advances in imaging secondary ion mass spectrometry for biological samples.生物样品成像二次离子质谱技术的进展。
Annu Rev Biophys. 2009;38:53-74. doi: 10.1146/annurev.biophys.050708.133634.
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Nanostructure-initiator mass spectrometry: a protocol for preparing and applying NIMS surfaces for high-sensitivity mass analysis.纳米结构引发剂质谱法：一种制备和应用用于高灵敏度质谱分析的NIMS表面的方法。
Nat Protoc. 2008;3(8):1341-9. doi: 10.1038/nprot.2008.110.
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Desorption electrospray ionization mass spectrometry: Imaging drugs and metabolites in tissues.解吸电喷雾电离质谱法：组织中药物及代谢物成像
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