Instituto de Ingeniería Biomédica, Universidad de Buenos Aires, Argentina.
Biomed Eng Online. 2010 Nov 4;9:68. doi: 10.1186/1475-925X-9-68.
Biomedical engineering is clearly present in modern neuroendocrinology, and indeed has come to embrace it in many respects. First, we briefly review the origins of endocrinology until neuroendocrinology, after a long saga, was established in the 1950's decade with quantified results made possible by the radioimmunoassay technique (RIA), a development contributed by the physical sciences. However, instrumentation was only one face of the quantification process, for mathematical models aiding in the study of negative feedback loops, first rather shyly and now at a growing rate, became means building the edifice of mathematical neuroendocrinology while computer assisted techniques help unravel the associated genetic aspects or the nature itself of endocrine bursts by numerical deconvolution analysis. To end the note, attention is called to the pleiotropic characteristics of neuroendocrinology, which keeps branching off almost endlessly as bioengineering does too.
生物医学工程在现代神经内分泌学中显然占有一席之地，并且在许多方面已经开始接受它。首先，我们简要回顾一下内分泌学的起源，直到神经内分泌学在 20 世纪 50 年代的几十年里，由于放射免疫分析技术（RIA）的出现，量化结果成为可能，这一技术的发展是物理科学的贡献。然而，仪器只是量化过程的一个方面，因为帮助研究负反馈回路的数学模型，最初相当谨慎，现在则以越来越快的速度，成为构建数学神经内分泌学的基础，而计算机辅助技术则通过数值反卷积分析帮助揭示相关的遗传方面或内分泌爆发的本质。在结束这篇笔记时，我们注意到神经内分泌学的多功能特性，它几乎像生物工程一样不断分支。
