B族链球菌、支原体及沙眼衣原体感染的定植与早期胚胎死亡所致自然流产的关系

[Relationship between the colonization of Group B Streptococci, Mycoplasma, and Chlamydia trachomatis infections and spontaneous abortion due to early embryonic death].

作者信息

Li Yong-hong, Wu Qin-lan, Zou Yi-mei, Pan Wei-fang, Peng Dan, Liu Xin-yan

机构信息

Department of Obstetrics and Gynecology, Shenzhen Shajing Affiliated Hospital, Guangzhou Medical University, Shenzhen, Guangdong 518104, China.

出版信息

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2010 Oct;32(5):513-5. doi: 10.3881/j.issn.1000-503X.2010.05.009.

DOI:10.3881/j.issn.1000-503X.2010.05.009

PMID:21050554

Abstract

OBJECTIVE

To explore the relationship between the colonization of group B streptococci (GBS), mycoplasma,and Chlamydia trachomatis (CT) infections and spontaneous abortion due to early embryonic death.

METHODS

Totally 74 patients (study group) who experienced the missed abortion during their first or second trimester and 62 women (control group) who underwent induced termination of normal pregnancy during the first or second trimester were enrolled in this study. The vaginal secretions, intrauterine aspirates, and amniotic fluids were collected for GBS culture. Cervical mycoplasma (UU+MH) and CT were detected at the same time.

RESULTS

Positive results of GBS culture of vaginal secretions were detected in 9 patients (12.16%) in the study group, but in only 6 patients (9.68%) in control group (P=0.662). The intrauterine aspirate samples (as well as the amniotic fluid samples) of all cases were negative in GBS culture. The positive rates of UU and MH were 32.43% (24/74) and 16.22% (12/74) in the study group, but were only 10.35% (12/62) (P=0.0103) and 6.45 (4/62) (P=0.042) in the control group. The positive rate of CT was 8.11% (6/74) in the study group and 8.06 % (5/62) in the control group (P=0.905). The rate of concurrent infection of GBS and mycoplasma was 4.05% (3/74) in the study group and 6.45% (4/62) in the control group (P=0.743). The rate of concurrent infection of GBS and CT was 0 in the study group and 1.61% (1/62) in the control group (P=0.475). The rate of concurrent mycoplasma and CT infection was 2.70% (2/74) in the study group and 0 in the control group (P=0.325). Furthermore, no one was positive for poly infection of all these three pathogens.

CONCLUSIONS

GBS may be positive in the genital tract of some pregnant women but is not related with early abortion. The mycoplasma infection may be one of the reasons leading to arrested intrauterine pregnancy.

摘要

目的

探讨B族链球菌（GBS）定植、支原体及沙眼衣原体（CT）感染与早期胚胎死亡所致自然流产之间的关系。

方法

本研究纳入74例在孕早期或孕中期发生稽留流产的患者（研究组）和62例在孕早期或孕中期接受人工终止正常妊娠的女性（对照组）。收集阴道分泌物、清宫组织及羊水进行GBS培养。同时检测宫颈支原体（UU+MH）及CT。

结果

研究组9例（12.16%）阴道分泌物GBS培养结果为阳性，而对照组仅6例（9.68%）阳性（P=0.662）。所有病例的清宫组织样本（以及羊水样本）GBS培养均为阴性。研究组UU和MH的阳性率分别为32.43%（24/74）和16.22%（12/74），而对照组分别仅为10.35%（12/62）（P=0.0103）和6.45%（4/62）（P=0.042）。研究组CT阳性率为8.11%（6/74），对照组为8.06%（5/62）（P=0.905）。研究组GBS与支原体合并感染率为4.05%（3/74），对照组为6.45%（4/62）（P=0.743）。研究组GBS与CT合并感染率为0，对照组为1.61%（1/62）（P=0.475）。研究组支原体与CT合并感染率为2.70%（2/74），对照组为0（P=0.325）。此外，无一人三种病原体多重感染呈阳性。