Langee H R
Clinical Faculty, University of Florida College of Medicine.
Am J Ment Retard. 1990 Jan;94(4):448-52.
Severely and profoundly mentally retarded institutionalized residents (N = 74) who received lithium carbonate for various behavior disorders were followed in a 10-year retrospective study. Their disorders had not been responsive to other medications or treatments. Behavioral data had been recorded regularly and coordinated with medication use. Subjects who demonstrated a sustained major reduction or elimination of behavioral symptoms were classified as lithium responders (n = 31). Characteristics that indicated greater likelihood of response included older age and presenting symptoms of psychosis, although all characteristics studied were seen in both the responder and nonresponder group.
对74名因各种行为障碍而在机构中接受碳酸锂治疗的重度和极重度智障居民进行了一项为期10年的回顾性研究。他们的疾病对其他药物或治疗均无反应。行为数据已定期记录，并与药物使用情况相协调。表现出行为症状持续大幅减轻或消除的受试者被归类为碳酸锂反应者（n = 31）。表明更有可能产生反应的特征包括年龄较大和出现精神病症状，尽管在反应者和非反应者组中都观察到了所有研究的特征。
