Mlodzik M, Hiromi Y, Weber U, Goodman C S, Rubin G M
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Cell. 1990 Jan 26;60(2):211-24. doi: 10.1016/0092-8674(90)90737-y.
The Drosophila seven-up (svp) gene was isolated as a lethal insertion in an "enhancer trap" screen. It is expressed and required in photoreceptor cell precursors R1, R3, R4, and R6 during eye development. The absence of svp+ function causes a transformation of these cells toward an R7 cell fate, as judged by morphology and expression of an R7-specific marker. This transformation depends in part on the sevenless gene product. Our results show that svp is involved in control of cell fate during the generation of neuronal diversity. Molecular analysis of svp reveals that it is a member of the steroid receptor gene superfamily and is likely to be a Drosophila homolog of the human transcription factor COUP.
果蝇七上（svp）基因是在“增强子陷阱”筛选中作为致死插入而分离出来的。它在眼睛发育过程中在光感受器细胞前体R1、R3、R4和R6中表达且是必需的。根据R7特异性标记的形态和表达判断，svp +功能的缺失会导致这些细胞向R7细胞命运转变。这种转变部分取决于无七基因产物。我们的结果表明，svp在神经元多样性产生过程中参与细胞命运的控制。对svp的分子分析表明，它是类固醇受体基因超家族的成员，可能是人类转录因子COUP的果蝇同源物。
