Lampugnani M G, Polentarutti N, Pedenovi M, Mantovani A, Dejana E, Colotta F
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Exp Cell Res. 1990 Feb;186(2):381-4. doi: 10.1016/0014-4827(90)90320-a.
Cultured human umbilical vein endothelial cells (HEC) could be induced to express c-fos and c-myc mRNA by either serum or ECGS (endothelial cell growth supplement). Neither agonist separately could support HEC proliferation but the combination did. Expression of c-fos and c-myc mRNA in the presence of both serum and ECGS was similar to that observed after each of the two stimuli was introduced separately. c-fos and c-myc expression in cultured HEC, even if related, is not necessarily accompanied by stimulation of cell growth.
培养的人脐静脉内皮细胞（HEC）可被血清或内皮细胞生长补充剂（ECGS）诱导表达c-fos和c-myc mRNA。单独任何一种激动剂都不能支持HEC增殖，但二者联合则可以。在血清和ECGS同时存在的情况下，c-fos和c-myc mRNA的表达与分别引入两种刺激后观察到的相似。培养的HEC中c-fos和c-myc的表达即使相关，也不一定伴随着细胞生长的刺激。
