具有细胞学表现的宫颈大细胞神经内分泌癌：一例报告
Cervical large cell neuroendocrine carcinoma with cytologic presentation: a case report.
作者信息
Niwa Kenji, Nonaka-Shibata Mayuko, Satoh Eriko, Hirose Yoshiyuki
机构信息
Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-city, Gifu 501-1194, Japan.
出版信息
Acta Cytol. 2010 Sep-Oct;54(5 Suppl):977-80.
BACKGROUND
Large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive cervical neoplasm. Few cytologic or colposcopic findings of LCNEC have been reported.
CASE
A 37-year-old woman, gravida 6, para 4, presented with vaginal bleeding for 3 months. The cervical smears showed cells dispersed as single cells or arranged as loosely cohesive sheets or glandlike aggregate and the nuclear size was almost 3-5 times larger than that of small lymphocytes. The cytologic, pathologic and immunohistochemical examinations suggested LCNEC. The patient underwent a radical hysterectomy and then received radiation and systemic chemotherapy.
CONCLUSION
Cytologic and colposcopic findings for LCNEC of the uterine cervix are reported. Patients with LCNEC have poor prognoses. Early diagnosis of the tumor is important.
背景
大细胞神经内分泌癌（LCNEC）是一种罕见且侵袭性强的宫颈肿瘤。关于LCNEC的细胞学或阴道镜检查结果报道较少。
病例
一名37岁女性，孕6产4，出现阴道出血3个月。宫颈涂片显示细胞呈单个细胞分散或呈松散黏附的片状或腺样聚集排列，核大小几乎是小淋巴细胞的3 - 5倍。细胞学、病理学和免疫组化检查提示为LCNEC。患者接受了根治性子宫切除术，随后接受放疗和全身化疗。
结论
报道了子宫颈LCNEC的细胞学和阴道镜检查结果。LCNEC患者预后较差。肿瘤的早期诊断很重要。
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