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西方社区三瓣膜手术的中期随访:生存预测因素

Mid-term follow up of triple valve surgery in a western community: predictors of survival.

作者信息

Hermans Hadewich, Tjahjono Markus, Faes Dirk, Belmans Ann, Meuris Bart, Herijgers Paul, Flameng Willem, Herregods Marie-Christine

机构信息

Department of Cardiology, University Hospitals Leuven, Belgium.

出版信息

J Heart Valve Dis. 2010 Sep;19(5):644-51; discussion 652.

Abstract

BACKGROUND AND AIM OF THE STUDY

Triple valve surgery remains a challenge, although with an improved survival rate compared to historical data. Aws assessment was made as to whether the type of valve surgery, underlying valve lesion and pathology were independent predictors of outcome. The patient characteristics were also described according to the type of surgery performed.

METHODS

A total of 166 consecutive patients underwent triple valve surgery and were followed up between October 1972 and June 2006. The clinical and operative variables were obtained retrospectively by physicians. The median follow up was 6.11 years (interquartile range 2.13-10.43).

RESULTS

The overall 30-day mortality was 10%, five-year survival 70%, and 10-year survival 60%. In patients with three mechanical valves, survival at five years was 90%, and 85% at 10 years, compared to 40% at five years and 30% at 10 years in patients with three bioprostheses. Among all patients with a mechanical valve in the aortic and mitral positions, those with a tricuspid bioprosthesis were compared to patients with tricuspid repair. The survival rate at 10 years was 60%, and similar between groups. The survival rate of patients with aortic and mitral bioprostheses and tricuspid repair was comparable to that in patients with three bioprostheses. Multivariable analyses showed that the type of tricuspid surgery, age, and NYHA functional class were each significant and independent predictors of survival, with a tricuspid mechanical prosthesis favoring survival. According to the type of surgery, the patient groups differed in their cardiovascular and non-cardiovascular risk profiles.

CONCLUSION

Triple-valve surgery is a difficult procedure, with greatly improved survival rates compared to historically reported data. The decision of prosthetic valve type and repair should be tailored to the individual patient, as both patient characteristics and chosen surgery appear to determine survival and morbidity. In young patients, a mechanical prosthesis should also be considered in the tricuspid position.

摘要

研究背景与目的

尽管与历史数据相比,三尖瓣手术的生存率有所提高,但它仍然是一项具有挑战性的手术。我们对瓣膜手术类型、潜在瓣膜病变和病理是否为结局的独立预测因素进行了评估。还根据所进行的手术类型描述了患者特征。

方法

1972年10月至2006年6月期间,共有166例连续接受三尖瓣手术的患者接受了随访。临床和手术变量由医生回顾性获取。中位随访时间为6.11年(四分位间距为2.13 - 10.43年)。

结果

总体30天死亡率为10%,五年生存率为70%,十年生存率为60%。在植入三个机械瓣膜的患者中,五年生存率为90%,十年生存率为85%;相比之下,植入三个生物瓣膜的患者五年生存率为40%,十年生存率为30%。在主动脉和二尖瓣位置植入机械瓣膜的所有患者中,将植入三尖瓣生物瓣膜的患者与进行三尖瓣修复的患者进行了比较。十年生存率为60%,两组之间相似。主动脉和二尖瓣植入生物瓣膜且三尖瓣修复的患者生存率与植入三个生物瓣膜的患者相当。多变量分析表明,三尖瓣手术类型、年龄和纽约心脏协会(NYHA)功能分级均为生存的显著且独立预测因素,三尖瓣植入机械瓣膜有利于生存。根据手术类型,患者组在心血管和非心血管风险特征方面存在差异。

结论

三尖瓣手术是一项困难的手术,与历史报告数据相比生存率有显著提高。人工瓣膜类型和修复的决策应根据个体患者进行调整,因为患者特征和所选手术似乎都决定了生存率和发病率。对于年轻患者,三尖瓣位置也应考虑植入机械瓣膜。

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