[变应性鼻炎患者生活质量的临床研究]
[Clinical research on the quality of life in patients with allergic rhinitis].
作者信息
Huang Zi-zhen, Zhang Ge-hua, Zhao Geng, Ye Jin, Liu Xian, Chen Yu-lian, Yang Qin-tai, Li Yuan
机构信息
Department of Otorhinolaryngology Head and Neck Surgery, Third Affiliated Hospital of SUN Yat-sen University, Guangzhou 510630, China.
出版信息
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Jun;45(6):450-4.
OBJECTIVE
To explore the quality of life (QOL) outcome in patients with allergic rhinitis (AR).
METHODS
A prospective trial was conducted to survey the QOL status of 101 AR patients, in contrast to that of 121 healthy individuals and 97 chronic pharyngitis (CP) patients by generic questionnaire medical outcomes study short-form 36-items health survey (SF-36), and to survey the most troublesome problems of AR patients by disease-specific questionnaire rhinoconjunctivitis quality of life questionnaire (RQLQ). The correlation between SF-36 and RQLQ had also been analyzed. All the results were analyzed statistically.
RESULTS
By the assessment of SF-36, the scores of 3 domains (x ± s, the same as follow, the scores were 78.02 ± 18.37, 56.13 ± 17.49, 78.81 ± 16.47, respectively) of AR patients were less than those (84.00 ± 18.36, 74.69 ± 14.13, 83.78 ± 14.31) of healthy individuals (P < 0.05), and the scores of 7 domains (the scores were: 91.78 ± 11.78, 79.16 ± 30.23, 78.02 ± 18.37, 56.13 ± 17.49, 78.81 ± 16.47, 67.66 ± 39.57, 68.78 ± 13.65, respectively) of AR patients were similar with those (94.12 ± 6.88, 80.67 ± 32.38, 73.57 ± 17.96, 59.73 ± 16.58, 80.41 ± 17.01, 63.58 ± 39.99, 66.43 ± 13.71) of CP patients (P > 0.05). By the assessment of RQLQ, in AR patients, both the nasal symptoms and the practical problems got the highest scores (the scores were 2.70 ± 1.29, 2.53 ± 1.37 respectively). According to the assessment of the correlation between SF-36 and RQLQ, the correlation was weak (r = -0.199 ∼ -0.526, P < 0.05).
CONCLUSIONS
The QOL of AR patients decreased compared with that of healthy individuals, but similar with that of CP patients. The most troublesome problems in AR patients were nasal symptoms and the practical problems. Both SF-36 and RQLQ were suitable for assessing the health status of AR patients. SF-36 and RQLQ each covered a different part of the QOL of AR patients, and the combination of the two questionnaires could improve the QOL measurement.
目的
探讨变应性鼻炎（AR）患者的生活质量（QOL）结局。
方法
进行一项前瞻性试验，通过通用问卷医学结局研究简表36项健康调查（SF - 36）对101例AR患者的QOL状况进行调查，并与121例健康个体和97例慢性咽炎（CP）患者进行对比，同时通过特异性疾病问卷变应性鼻结膜炎生活质量问卷（RQLQ）调查AR患者最困扰的问题。还分析了SF - 36与RQLQ之间的相关性。所有结果均进行统计学分析。
结果
通过SF - 36评估，AR患者3个领域的得分（x ± s，下同，得分分别为78.02 ± 18.37、56.13 ± 17.49、78.81 ± 16.47）低于健康个体（84.00 ± 18.36、74.69 ± 14.13、83.78 ± 14.31）（P < 0.05），AR患者7个领域的得分（得分分别为：91.78 ± 11.78、79.16 ± 30.23、78.02 ± 18.37、56.13 ± 17.49、78.81 ± 16.47、67.66 ± 39.57、68.78 ± 13.65）与CP患者（94.12 ± 6.88、80.67 ± 32.38、73.57 ± 17.96、59.73 ± 16.58、80.41 ± 17.01、63.58 ± 39.99、66.43 ± 13.71）相似（P > 0.05）。通过RQLQ评估，在AR患者中，鼻部症状和实际问题得分最高（得分分别为2.70 ± 1.29、2.53 ± 1.37）。根据对SF - 36与RQLQ相关性的评估，相关性较弱（r = -0.199 ∼ -0.526，P < 0.05）。
结论
AR患者的QOL较健康个体下降，但与CP患者相似。AR患者最困扰的问题是鼻部症状和实际问题。SF - 36和RQLQ均适用于评估AR患者的健康状况。SF - 36和RQLQ分别涵盖了AR患者QOL的不同部分，两者问卷结合可改善QOL测量。
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