白天血浆中优球蛋白溶解时间、组织型纤溶酶原激活物以及游离和总纤溶酶原激活物抑制剂水平的波动情况。

Fluctuations of euglobulin lysis time, tissue plasminogen activator, and free and total plasminogen activator inhibitor levels in plasma in daytime.

作者信息

Takada A, Takada Y, Urano T, Sakakibara K, Rydzewski A

机构信息

Department of Physiology, Hamamatsu University, School of Medicine, Shizuoka-ken, Japan.

出版信息

Thromb Res. 1990 Jan 1;57(1):13-20. doi: 10.1016/0049-3848(90)90191-e.

DOI:10.1016/0049-3848(90)90191-e

PMID:2105539

Abstract

Blood was taken from healthy 15 males and 10 females at 9:30 h, 10:00 h and 12:30 h. The euglobulin fraction was prepared and clotted by the addition of human thrombin. The clot lysis time shortened significantly from 9:30 h to 10:00 h (p less than 0.01) and further to 12:30 h (p less than 0.01). Plasma levels of tissue plasminogen activator (t-PA) antigens did not change from 9:30 h to 10:00 h, but slightly and significantly to 12:30 h (p less than 0.01). Plasma levels of free plasminogen activator inhibitor-1 (PAI-1) and complex of t-PA-PAI-1 decreased from 9:30 h to 10:00 h (p less than 0.02) and to 12:30 h (p less than 0.01). Plasma levels of total PAI-1 (free plus complex) decreased from 9:30 h to 10:00 h (p less than 0.01) and to 12:30 h (p less than 0.01). These results suggest that a major factor contributing to the enhanced fibrinolytic activity of the euglobulin fraction may be a level of PAI-1 (free and total).

摘要

在上午9:30、10:00和12:30采集了15名健康男性和10名健康女性的血液。制备优球蛋白组分，并通过添加人凝血酶使其凝固。从9:30到10:00，凝块溶解时间显著缩短（p<0.01），到12:30进一步缩短（p<0.01）。组织纤溶酶原激活物（t-PA）抗原的血浆水平从9:30到10:00没有变化，但到12:30有轻微且显著的变化（p<0.01）。游离纤溶酶原激活物抑制剂-1（PAI-1）和t-PA-PAI-1复合物的血浆水平从9:30到10:00降低（p<0.02），到12:30也降低（p<0.01）。总PAI-1（游离加复合物）的血浆水平从9:30到10:00降低（p<0.01），到12:30也降低（p<0.01）。这些结果表明，导致优球蛋白组分纤溶活性增强的一个主要因素可能是PAI-1（游离和总）的水平。