血浆中组织型纤溶酶原激活物（TPA）和纤溶酶原激活物抑制剂-1（PAI-1）抗原水平的波动：男女之间波动模式的差异

Fluctuation of TPA and PAI-1 antigen levels in plasma: difference of their fluctuation patterns between male and female.

作者信息

Urano T, Sumiyoshi K, Nakamura M, Mori T, Takada Y, Takada A

机构信息

Department of Physiology and Surgery, Hamamatsu University, School of Medicine, Shizuoka-ken, Japan.

出版信息

Thromb Res. 1990 Oct 1;60(1):55-62. doi: 10.1016/0049-3848(90)90339-e.

DOI:10.1016/0049-3848(90)90339-e

PMID:2126149

Abstract

The daytime fluctuation of the fibrinolytic activity and the antigen levels of tissue plasminogen activator (tPA) and plasminogen activator inhibitor 1 (PAI-1) in plasma were analyzed in normal male and female volunteers. Samples were obtained at 8:30, 10:30, 12:30, 14:30 and 16:30 h. Euglobulin clot lysis time (ECLT) showed the longest time at 8:30 to 10:30 h and the shortest time at 16:30 h. The highest level of tPA was obtained at 8:30 h and the lowest at 14:30 h in men, whereas the highest value was at 8:30 h and the lowest was at 16:30 h in females. Active free PAI-1 showed highest value at 10:30 h in men and at 8:30 h in women. The lowest values obtained at 16:30 h in both men and women and were about one third of the highest values. ECLT was always shorter in females than in males and parameter such as tPA and PAI-1 were also lower in females than in males. The phase of the circadian rhythm of the fibrinolytic parameters may be advanced in females than in males.

摘要

对正常男性和女性志愿者血浆中纤维蛋白溶解活性以及组织纤溶酶原激活物（tPA）和纤溶酶原激活物抑制剂1（PAI-1）抗原水平的日间波动情况进行了分析。在8:30、10:30、12:30、14:30和16:30采集样本。优球蛋白凝块溶解时间（ECLT）在8:30至10:30时最长，在16:30时最短。男性tPA水平在8:30时最高，在14:30时最低，而女性最高值在8:30时，最低值在16:30时。活性游离PAI-1在男性中于10:30时显示最高值，在女性中于8:30时显示最高值。男性和女性在16:30时获得的最低值约为最高值的三分之一。女性的ECLT始终比男性短，tPA和PAI-1等参数在女性中也比男性低。纤维蛋白溶解参数的昼夜节律阶段在女性中可能比男性提前。