Department of Brain Science and Engineering, Kyushu Institute of Technology, Wakamatsu, Kitakyushu, Fukuoka 808-916, Japan.
Behav Brain Res. 2011 Mar 1;217(2):309-14. doi: 10.1016/j.bbr.2010.10.031. Epub 2010 Nov 3.
Our previous study showed that social interactions induce inhibitory and facilitatory modulations of avoidance behavior under both safe and dangerous situations in rats. To understand the neural mechanisms for these phenomena, we investigated the effects of bilateral lesions of the medial prefrontal cortex (mPFC) on the social modulation of avoidance behavior. We found that the lesions did not impair but actually augmented both social inhibition and facilitation of avoidance. These results suggest that the mPFC in rodents plays a suppressive role in the social modulation of avoidance.
我们之前的研究表明，在安全和危险两种情况下，社会互动会引起大鼠回避行为的抑制和促进调节。为了理解这些现象的神经机制，我们研究了双侧前额叶皮层（mPFC）损伤对回避行为的社会调节的影响。我们发现，损伤不仅没有损害，反而实际上增强了回避行为的社会抑制和促进。这些结果表明，啮齿动物的 mPFC 在回避行为的社会调节中发挥抑制作用。
