Department of Biomedical Sciences, Tuskegee University, Tuskegee, AL 36088, USA.
Peptides. 2011 Feb;32(2):241-5. doi: 10.1016/j.peptides.2010.10.027. Epub 2010 Nov 3.
In mammals, gastrin releasing peptide (GRP) 10 and 27 reduce food intake. In the current work, we test the hypothesis that GRP-29, the large molecular form of GRP in the rat, also evokes feeding responses consistent with a possible role in satiety. Here, we measured three feeding responses, size of first meal, intermeal interval (IMI, time between first and second meal) and satiety ratio (SR, satiation period for every unit of food consumed in the first meal), in overnight food deprived rats following GRP-10, 27 or 29 (0, 0.3, 1.0, 2.1, 4.1, 10.3, 17.2nmol/kg) intraperitoneally and presentation of a 10% sucrose test diet. GRP-29 and GRP-27 reduced the size of the first meal, prolonged IMI and increased SR, but GRP-10 failed to exhibit similar feeding responses. The order of potency was GRP-29=GRP-27>GRP-10. The current data support a role for GRP-29 in the short-term regulation of food intake.
在哺乳动物中，胃泌素释放肽（GRP）10 和 27 可减少食物摄入。在目前的工作中，我们检验了这样一个假设，即 GRP-29（大鼠中 GRP 的大分子形式）也会引发进食反应，这与其在饱腹感中的可能作用一致。在这里，我们在经过一夜禁食的大鼠中测量了三种进食反应，即第一餐的大小、进食间隔时间（IMI，第一餐和第二餐之间的时间）和饱食比（SR，第一餐中每单位食物的饱食期），腹腔内注射 GRP-10、27 或 29（0、0.3、1.0、2.1、4.1、10.3、17.2nmol/kg），并提供 10%蔗糖测试饮食。GRP-29 和 GRP-27 减少了第一餐的大小，延长了 IMI 并增加了 SR，但 GRP-10 未能表现出类似的进食反应。效力顺序为 GRP-29=GRP-27>GRP-10。目前的数据支持 GRP-29 在短期调节食物摄入中的作用。
