儿童肝脏肿瘤和代谢性疾病。
Hepatic neoplasia and metabolic diseases in children.
机构信息
Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
出版信息
Clin Liver Dis. 2010 Nov;14(4):731-46. doi: 10.1016/j.cld.2010.07.002.
Hepatic neoplasia is a rare but serious complication of metabolic diseases in children. The risk of developing neoplasia, the age at onset, and the measures to prevent it differ in various diseases. This article reviews the most common metabolic disorders in humans that are associated with neoplasms, with a special emphasis on the molecular etiopathogenesis of this process. The cellular pathways driving carcinogenesis are poorly understood, but best known in tyrosinemia.
肝肿瘤是儿童代谢性疾病的罕见但严重的并发症。不同疾病发生肿瘤的风险、发病年龄和预防措施均有所不同。本文综述了与肿瘤相关的人类最常见的代谢紊乱，并特别强调了该过程的分子发病机制。推动肿瘤发生的细胞途径尚未完全了解，但在酪氨酸血症中最为人所知。
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