Woode G N, Bew M E, Dennis M J
Vet Rec. 1978 Jul 8;103(2):32-4. doi: 10.1136/vr.103.2.32.
Inoculation at birth with a live attenuated strain of a bovine rotavirus isolated in the USA (scourvax-reo) induced protection in five gnotobiotic calves seven to 21 days later against a UK isolate of pathogenic bovine rotavirus. However, no protection was induced in three calves challenged three to five days after vaccination. There was a close antigenic relationship demonstrated between the two bovine rotavirus isolates. In contrast only one of three gnotobiotic calves inoculated with foal rotavirus, and one of three with human rotavirus, were protected against bovine rotavirus challenge. Protection in these two calves correlated with high heterologous immunofluorescent antibody titre (320 or greater), although the neutralising antibody titres was less than 20.
出生时用在美国分离出的牛轮状病毒减毒株(scourvax - reo)进行接种,7至21天后,五只无菌犊牛获得了针对一株英国致病性牛轮状病毒分离株的保护。然而,在接种疫苗后3至5天接受攻击的三只犊牛中未诱导出保护作用。这两种牛轮状病毒分离株之间显示出密切的抗原关系。相比之下,接种马轮状病毒的三只无菌犊牛中只有一只,接种人轮状病毒的三只中也只有一只受到了针对牛轮状病毒攻击的保护。这两只犊牛中的保护作用与高异源免疫荧光抗体滴度(320或更高)相关,尽管中和抗体滴度小于20。